MOTS-C 10mg
MOTS-c (Mitochondrial ORF of the 12S rRNA-c)
MOTS-c is a unique and relatively new peptide that has gained significant attention in the fields of metabolic health and longevity.
MOTS-c: The "Exercise Mimetic" Peptide for Metabolic Health
MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP), meaning it is encoded by DNA within the mitochondria (the cell's "powerhouse"), setting it apart from peptides encoded in the nuclear DNA. It acts as a signaling molecule that facilitates essential communication between the mitochondria and the rest of the cell.
Key Actions and Reported Effects (Often termed an "Exercise Mimetic"):
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Metabolic Regulation: Its primary function is to act as a metabolic master switch, chiefly by activating the AMP-activated protein kinase (AMPK) pathway.
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Improved Insulin Sensitivity: MOTS-c enhances the efficiency of glucose utilization, particularly in skeletal muscle, leading to improved insulin sensitivity and better blood sugar control. This action has been compared to that of the diabetes drug metformin.
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Fat Loss & Energy: It promotes the use of stored fat for fuel (fat oxidation) and helps the body maintain metabolic homeostasis, potentially aiding in the prevention of diet-induced obesity.
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Physical Performance: Research suggests MOTS-c can improve endurance, muscle function, and overall physical capacity, especially in aging subjects, thereby mimicking some of the systemic benefits of physical exercise.
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Anti-Aging/Longevity: By enhancing mitochondrial function and metabolic balance—processes that decline with age—it is a subject of intense research for its potential role in extending healthspan and combating age-related diseases like type 2 diabetes and cardiovascular decline.
Important Considerations & Safety:
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Unapproved Status: MOTS-c is an experimental peptide and is not approved by the FDA for human therapeutic use. It is often sold for research purposes only.
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Prohibited in Sport: It is specifically listed on the World Anti-Doping Agency (WADA) Prohibited List as a metabolic modulator.
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Administration: In research settings and unapproved applications, it is typically administered via subcutaneous injection.
Disclaimer: The information provided is for educational purposes only and is based on preclinical and early-stage human research. MOTS-c is not an approved drug, and its safety and efficacy for human use are still under investigation.